Publications 1 페이지

Publications list
Title	Contents
Int Immunopharmacology 81 (2020) 106257	NecroX-5 alleviate lipopolysaccharide-induced acute respiratory distress syndrome by inhibiting TXNIP/NLRP3 and NF-κB
Mucosal Immunology 12: 1070-1081 (2019)	Regulation of HMGB1 release protects chemoradiotherapy-associated mucositis
Int Immunopharmacology 66: 139-145 (2019)	NecroX-5 ameliorates inflammation by skewing macrophages to the M2 phenotype
British J Clinical pharmacology 83: 1205-1215 (2017)	Pharmacokinetics and safety of a single dose of the novel necrosis inhibitor LC28‐0126 in healthy male subjects
Atherosclerosis 252: 166-174 (2016)	NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice
Korean J Physiol Pharmacol. 20: 305-314 (2016)	NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFa/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts.
Kor J Physiol Pharmacol. 20: 201-211 (2016)	NecroX-5 protects mitochondrial oxidative phosphorylation capacity and preserves PGC-1α expression levels during hypoxia/reoxygenation injury.
Transplant Proc. 48: 199-204 (2016)	Beneficial effects of necrosis modulator, indole derivatives NecroX-7, on renal ischemia-reperfusion injury in rats.
Arch Plast Surg. 42: 789-791 (2015)	Effects of NecroX-5 on the survival of a random pattern skin flap in mice.
Allergy. 71: 198-209 (2015)	NecroX-5 suppresses IgE/Ag-stimulated anaphylacxis and mast cell activation by regulating the SHP-1-Syk signaling module.
Sci Rep. 5: 17784 (2015)	Drug signature-based finding of additional clinical use of LC28-0126 for neutrophilic bronchial asthma.
J Immunol. 194: 5223-5232 (2015)	The free radical scavenger NecroX-7 attenuates acute-graft-versus-host disease via receiprocal regulation of Th1/regulatory T cells and inhibition of HMGB1 release.
Nat Med. 20:503-510 (2014)	Essential Role for Autophagy in the Maintenance of Immunological Memory Against Influenza Infection.
J Clin Invest. 124:3987-4003 (2014)	Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.
Immunity. 41:1001-1012 (2014)	Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis.
Liver International. 35: 1341-1353 (2014)	The indole derivative NecroX-7 improves nonalcholic statohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation.
Cell Death Dis. 5: e1498 (2014)	NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation.
Toxicol Sci. 140: 393-402 (2014)	BNIP3 upregulation by ERK and JNK mediates cadmium-induced necrosis in neuronal cells.
Cell Biol Int. 38: 702-707 (2014)	NecroX-5 suppresses sodium nitroprusside-induced cardiac cell death through inhibition of JNK and caspase-3 activation.
Arch Toxicol. 88: 435-441 (2014)	Protective role of NecroX-5 against neomycin-induced hair cell damage in zebrafish.
Cell. 153:521–534 (2013)	TNF Dually Mediates Resistance and Susceptibility to Mycobacteria Through Mitochondrial Reactive Oxygen Species.
Antioxid Redox Signal. 14: 1713-1722 (2013)	An indole derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice.
Life Sci. 91: 928-934 (2012)	A novel small molecule, NecroX-7, inhibits osteoclast differentiation by suppressing NF-Kb activity and c-Fos expression.
Int J Pediatr Otorhinolaryngol. 76: 1265-1269 (2012)	Protective effect of NecroX, a novel necroptosis inhibitor, on gentamycin-induced ototoxicity.
Toxicol Appl Pharmacol. 263: 1-6 (2012)	NecroX-7 prevents oxidative stress-induced cardiomyopathy by inhibition of NADPH oxidase activity in rats.
Cardiovasc Research. 94: 342-350 (2012)	NecroX-5 prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.
Am J Physiol Heart Circ Physiol. 301: H1004-1014 (2011)	Creation of myocardial fibrosis by transplantation of fibroblasts primed with survival factors.
Arch Pharm Res. 33: 1813-1823 (2010)	NecroX as a novel class of mitochondrial reactive oxygen species and ONOO- scavenger.
Transplant Proc. 42: 3414-3421(2010)	Effect of necrosis modulator NecroX-7 on hepatic ischemia-reperfusion injury in beagle dogs.

Discovering and developing therapeutics

Publications